Anti-Claudin-4 Antibody, clone 10B4.3

半岛bd体育手机客户端 说明

一般描述

Claudin 4, also known as Clostridium perfringens enterotoxin receptor, or CPE-R, or CPE-receptor or Williams-Beuren syndrome chromosomal region 8 protein, and encoded by the gene CLDN4/CPER/CPETR1/WBSCR8, plays a critical role in tight junction specific obliteration of intercellular space. Claudin 4 directly interacts with several important tight junction associated proteins including ZO-1,2,3 and EPHA2 proteins, and through these interactions, Claudin 4 regulates tight junction formation. Claudin 4 is localized to cell junctions and membranes at tight junctions. Claudin 4 is expressed in most tissues particularly in intestine, liver, and pancreas. Defects in Claudin 4 may be associated with Williams Beuren syndrome genetic deletion syndrome. Claudin 4 is also over expressed in many cancers and thus is a target of anti-cancer research using C. perfringens enterotoxin.

免疫原

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Claudin-4.
Epitope: Cytoplasmic domain

应用

Research Category
Cell Structure
Western Blotting Analysis: 2.0 ?g/mL from a representative lot detected Claudin-4 in 10 ?g of MCF-7 cell lysate.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Claudin-4 in human ileum and human tonsil tissue.
Research Sub Category
ECM Proteins
Anti-Claudin-4 Antibody, clone 10B4.3 is an antibody against Claudin-4 for use in western blotting & IHC (Paraffin).

质量

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 2.0 ?g/mL of this antibody detected Claudin-4 in 10 ?g of HeLa cell lysate.

目标描述

~ 22 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified antibody
antibody product type	primary antibodies
克隆	10B4.3, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_001296
UniProt登记号	O14493
运输	wet ice
Gene Information	human ... CLDN4(1364)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable