Anti-Claudin-1 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Anti-Claudin-1 is produced in rabbit using as immunogen a synthetic peptide corresponding to a sequence located at the C-terminal region of human claudin-1, conjugated to KLH. Claudin-1 (also known as CLDN1, senescence-associated epithelial membrane protein (SEMP1) and ILVASC) is a 22 kDa protein. It is expressed at high levels in kidney and liver and at lower levels in spleen, heart, brain, lung and testis. Claudins are located in both epithelial and endothelial cells in tissues. Claudins consist of four transmembrane domains and two extracellular loops, required to form tight junction strands. CLDN1 gene is located on human chromosome 3q28.

免疫原

synthetic peptide corresponding to a sequence located at the C-terminal region of human claudin-1, conjugated to KLH. The corresponding sequence is identical in rat claudin-1 and highly conserved (single amino acid substitution) in mouse claudin-1.

应用

Anti-Claudin-1 antibody produced in rabbit has been used in immunohistochemistry and immunoblotting,

生化/生理作用

Claudin-1 is frequently up-regulated in colorectal carcinomas (CRCs), resulting in tumor differentiation and progression. Defects in the gene encoding claudin-1 are the cause of an autosomal recessive syndrome named ichthyosis-sclerosing cholangitis neonatal (NISCH). It participates in the barrier formation of tight junction. It modulates the tight junctions in human airway epithelium. CLDN1 acts as a receptor for the hepatitis C virus entry.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen ~23 kDa
species reactivity	rat, human
浓度	~1.0 mg/mL
technique(s)	immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat kidney. western blot: 1.5-3.0 μg/mL using extracts of rat kidney (S1 fraction).
UniProt登记号	O95832
运输	dry ice
储存温度	?20℃
Gene Information	human ... CLDN1(9076) rat ... Cldn1(65129)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable