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位置: 首页> 品牌> Sigma-Aldrich> Anti-CKAP4 Antibody, clone 9C4.4

Anti-CKAP4 Antibody, clone 9C4.4

品牌
Sigma-Aldrich
货号
MABC153
规格纯度
clone 9C4.4, from mouse
价格
4893.96 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-CKAP4 Antibody, clone 9C4.4
Cytoskeleton-associated protein 4, 63-kDa cytoskeleton-linking membrane protein, Climp-63, p63
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cytoskeleton-associated protein 4, also known as 63-kDa cytoskeleton-linking membrane protein or Climp-63 or p63, and encoded by the gene CKAP4, is an integral membrane protein that links the endoplasmic reticulum (ER) to microtubules. The binding of CKAP4 is dependent upon its phosphorylation state: dephosphorylated CKAP4 binds microtubules and phosphorylated CKAP4 does not bind microtubules. CKAP4 is localized to the endoplasmic reticulum membrane and plasma membrane; CKAP4 is also found in the cytoplasm and perinuclear regions upon APF stimulation. CKAP4 is expressed is a wide variety of cell types and tissues and CKAP4 appears to be critical for antibiotic cytotoxicity for certain drugs like Gentamycin which bind the drug and cause CKAP4 to dimerize and malfunction.

免疫原

GST-tagged recombinant protein corresponding to the coiled coil domain of human CKAP4.
Epitope: coiled coil domain

应用

Research Sub Category
Apoptosis - Additional
Detect Cytoskeleton-associated protein 4 using this mouse monoclonal antibody, Anti-CKAP4 Antibody & clone 9C4.4 validated for use in western blotting.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.2 ?g/mL of this antibody detected CKAP4 in 10 ?g of HeLa cell lysate.

目标描述

~ 65 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 9C4.4, monoclonal
species reactivity human
technique(s) western blot: suitable
同位素/亚型 IgG2aκ
NCBI登记号 NP_006816
UniProt登记号 Q07065
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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