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位置: 首页> 品牌> Sigma-Aldrich> 抗顺铂 DNA 加合物抗体,克隆 ICR4

Anti-Cisplatin DNA Adducts Antibody, clone ICR4

抗顺铂 DNA 加合物抗体,克隆 ICR4

品牌
Sigma-Aldrich
货号
MABE416
规格纯度
clone 1CR4, from rat
价格
5206.52 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Cisplatin DNA Adducts Antibody, clone ICR4
CP9/19, Cisplatin DNA modification
抗顺铂 DNA 加合物抗体,克隆 ICR4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cisplatin adducts are Guanine-Guanine (GG) DNA intrastrand cross links caused by the chemical compound Cisplatin. Cisplatin is used as a chemotherapy agent that contains platinum. The crosslinking of the DNA triggers apoptosis in the effected cell. Cisplatin is particularly effective in certain cancers such as testicular cancer. Unfortunately like most chemotherapy agents Cisplatin has many side effects and cancer cells typically will develop resistance to the drug after a period of time. Clone ICR4 was formerly known as clone CP9/19.

特异性

This antibody demonstrates specificity for cisplatin modified DNA.

免疫原

Cisplatin modified native DNA.

应用

Detect Cisplatin adducts using this rat monoclonal antibody, Anti-Cisplatin DNA Adducts Antibody, clone ICR4 validated for use in Dot Blot, ELISA & IHC.
ELISA Analysis: A representative lot from an independent laboratory detected Cisplatin DNA Adducts in ELISA (Tilby, M. J., et al. (1991). Cancer Res. 51(1):123-129.; Kothandapani, A., et al. (2011). J Biol Chem. 286(16):14564-14574.; Welters, M. J., et al. (1999). Ann Oncol. 10(1):97-103.; Strobeck, M. W., et al. (2000). Proc Natl Acad Sci USA. 97(14):7748-7753.; Kothandapani, A., et al. (2012). Exp Cell Res. 18(16):1973-1986.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Cisplatin DNA Adducts in Head and Neck Squamous Cell Carcinoma tissues. (Welters, M. J., et al. (1999). Ann Oncol. 10(1):97-103.).
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology

质量

Evaluated by Dot Blot in untreated and Cisplatin treated DNA from HeLa cell lysates.

Dot Blot Analysis: A 1:1,000 dilution of this antibody detected Cisplatin DNA Adducts in 1.0 and 0.5 ?g of Cisplatin treated DNA from HeLa cell lysates.

外形

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
抗体形式 purified antibody
antibody product type primary antibodies
克隆 1CR4, monoclonal
species reactivity human
technique(s) ELISA: suitable
dot blot: suitable
immunohistochemistry: suitable
同位素/亚型 IgG2aκ
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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