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位置: 首页> 品牌> Sigma-Aldrich> Anti-Chd2, clone 8H3 Antibody

Anti-Chd2, clone 8H3 Antibody

品牌
Sigma-Aldrich
货号
MABE873
规格纯度
clone 8H3, from rat
价格
5854.74 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-Chd2, clone 8H3 Antibody
SNF2 chromatin remodelling enzyme, Chromodomain Helicase DNA Binding Protein 2, Protein Chd2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Chd2, also known as Chromodomain-helicase-DNA-binding protein 2 (CHD-2), or ATP-dependent helicase CHD2, and encoded by the gene CHD2, belongs to the CHD family of proteins. This family is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes are chromatin remodeling proteins and alter gene expression by modifying the chromatin structure of a particular gene. The alteration affects the access of the transcriptional apparatus to it, and thus the gene’s expression. In the mouse Chd2 is expressed in heart, forebrain, extremities, and facial and dorsal regions during specific times of embryonic development. Chd2 null mice are embryonic lethal, and in humans, various mutations in CHD-2 gene appear to cause a variety of disorders and developmental defects. Other mutations associated with the CHD2 gene locus appear to cause childhood-onset epileptic encephalopathy (EEOC).

免疫原

Recombinant protein corresponding to mouse Chd2.

应用

This Anti-Chd2 antibody, clone 8H3 is validated for use in western blotting, IP, ICC & ChIP for the detection of Chd2.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Chd2 from C2C12 cell lysate (Harada, A., et al. (2012). EMBO J. 31(13):2994-3007.).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Chd2 in C2C12 cells (Harada, A., et al. (2012). EMBO J. 31(13):2994-3007.).

Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Chd2 from C2C12 cell lysate (Harada, A., et al. (2012). EMBO J. 31(13):2994-3007.).

质量

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 1 ?g/mL of this antibody detected Chd2 in 10 ?g of Jurkat cell lysate.

目标描述

~211 kDa observed. Uncharacterized band(s) may be observed in some cell lysates. Two known isoforms may be observed at 50 kDa and 200 kDa

外形

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 8H3, monoclonal
species reactivity mouse, human
technique(s) ChIP: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型 IgG2aκ
NCBI登记号 NP_001074814
UniProt登记号 E9PZM4
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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