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位置: 首页> 品牌> Sigma-Aldrich> Anti-CHD7 Antibody

Anti-CHD7 Antibody

品牌
Sigma-Aldrich
货号
ABS453
规格纯度
from rabbit, purified by affinity chromatography
价格
5854.74 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-CHD7 Antibody
Chromodomain helicase DNA binding protein 7, CHD-7, IS3, KAL5, ATP-dependent helicase CHD7
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Chromodomain-helicase-DNA-binding protein 7 (CHD7), also known as ATP-dependent helicase CHD7, belongs to a superfamily of proteins of the ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. CHD7 may play an important role in early embryonic development by affecting chromatin structure and gene expression. CHD7 interacts with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes. Defects in CHD7 are suggested to be the cause of CHARGE syndrome (CHARGES) and idiopathic scoliosis type 3 (IS3). Mutations in CHD7 may also result in hypogonadotropic hypogonadism (HH5). CHD7 is widely expressed in fetal and adult tissues.

免疫原

KLH-conjugated linear peptide corresponding to human CHD7.

应用

Anti-CHD7 Antibody is a highly specific rabbit polyclonal antibody, that targets CHD7 & has been tested in western blotting & IHC.
Research Category
Epigenetics & Nuclear Function
Immunohistochemistry Analysis: 5 ?g/mL from a representative lot detected CHD7 in mouse brain tissue.
Research Sub Category
Chromatin Biology

质量

Evaluated by Western Blotting in SK-N-SH cell lysate.

Western Blotting Analysis: 2 ?g/mL of this antibody detected CHD7 in 15 ?g of SK-N-SH cell lysate.

目标描述

~290 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~128 kDa and ~336 kDa

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
SK-N-SH cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity mouse, human
technique(s) immunohistochemistry: suitable
western blot: suitable
UniProt登记号 Q9P2D1
运输 wet ice
Gene Information human ... CHD7(55636)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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