半岛bd体育手机客户端 说明
一般描述
Chromodomain-helicase-DNA-binding protein 7 (CHD7), also known as ATP-dependent helicase CHD7, belongs to a superfamily of proteins of the ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. CHD7 may play an important role in early embryonic development by affecting chromatin structure and gene expression. CHD7 interacts with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes. Defects in CHD7 are suggested to be the cause of CHARGE syndrome (CHARGES) and idiopathic scoliosis type 3 (IS3). Mutations in CHD7 may also result in hypogonadotropic hypogonadism (HH5). CHD7 is widely expressed in fetal and adult tissues.
免疫原
KLH-conjugated linear peptide corresponding to human CHD7.
应用
Anti-CHD7 Antibody is a highly specific rabbit polyclonal antibody, that targets CHD7 & has been tested in western blotting & IHC.
Research Category
Epigenetics & Nuclear Function
Immunohistochemistry Analysis: 5 ?g/mL from a representative lot detected CHD7 in mouse brain tissue.
Research Sub Category
Chromatin Biology
质量
Evaluated by Western Blotting in SK-N-SH cell lysate.
Western Blotting Analysis: 2 ?g/mL of this antibody detected CHD7 in 15 ?g of SK-N-SH cell lysate.
目标描述
~290 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~128 kDa and ~336 kDa
外形
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
SK-N-SH cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | mouse, human |
technique(s) | immunohistochemistry: suitable western blot: suitable |
UniProt登记号 | Q9P2D1 |
运输 | wet ice |
Gene Information | human ... CHD7(55636) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich