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位置: 首页> 品牌> Sigma-Aldrich> Anti-CDKN2A (Isoform 1)/P16INK4A antibody produced in goat

Anti-CDKN2A (Isoform 1)/P16INK4A antibody produced in goat

品牌
Sigma-Aldrich
货号
SAB2500221
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-CDKN2A (Isoform 1)/P16INK4A antibody produced in goat
Anti-Cyclin-dependent kinase inhibitor 2A
Anti-p16INK4a
Anti-HGNC:1787
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cyclin dependent kinase inhibitor 2A (CDKN2A), also known as P16-INK4A, belongs to the Ink4 (inhibitor of CDK4) family of CDK inhibitors. It is encoded by the gene mapped to human chromosome 9p21 within the INK4a/ alternate reading frame (ARF) locus. Human P16-INK4A is localized in both nucleus and cytoplasm, and its expression increases with ageing in skin and kidney tissues.

免疫原

Peptide with sequence C-HARIDAAEGPSDIPD from the C Terminus of the protein sequence according to NP_000068.1.

生化/生理作用

Cyclin dependent kinase inhibitor 2A (CDKN2A), also known as P16-INK4A, arrests cell cycle progression by inhibiting S-phase and promotes apoptosis. The encoded protein has anti-proliferative biological activity, and is implicated in the retinoblastoma (Rb) protein pathway. P16-INK4A acts as a tumor suppressor and plays a vital role in ageing and cellular senescence. Increased expression of this protein might lead to various types of high grade cancers. P16-INK4A also facilitates cell invasion and angiogenesis. Bronchial lavage P16INK4A promoter methylation might function as a potential biomarker for diagnosis of lung cancer.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD00282397
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 goat
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human
technique(s) immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号 P42771
运输 dry ice
储存温度 ?20℃
Gene Information human ... CDKN2A(1029)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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