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一般描述

The gene CDK11A (cyclin dependent kinase 11A) is mapped to human chromosome 1p36.33. Human genome contains two genes for CDK11, CDK11A and CDK11B. Both genes have three isoforms, the long CDK11^p110, short CDK11^p58and CDK11^p46. CDK11^p110is present in the nucleus, CDK11^p58is present in the nucleus and cytoplasm, and CDK11^p46is in the cytoplasm. CDK11^p58is mainly expressed in the G2/M phase. CDK11^p110is expressed during the whole cell cycle. The CDK11A protein has many NLSs (nuclear localization sequences), a 14-3-3 consensus site, an arginine/glutamic acid domain (RE domain), a poly-glutamic acid domain (poly-E domain) and a carboxy-terminal catalytic domain.

免疫原

PITSLRE serine/threonine-protein kinase CDC2L2 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

CDK11 (cyclin dependent kinase 11) regulates transcription and RNA processing (mainly alternate splicing) by binding to L-type cyclins. It is also involved in cellular responses, such as hormone receptor signaling and autophagy. CDK11^p58is needed for duplication of the centrioles, spindle rearrangement and sister chromatid cohesion at centromeres. CDK11 plays an important role in cancer cell growth and proliferation by regulating cell death.

特点和优势

Prestige Antibodies^?are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^?to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST76478.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

基本信息

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安全信息