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Anti-CDH1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300693
规格纯度
affinity isolated antibody
价格
4618.16 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-CDH1 antibody produced in rabbit
Anti-UVO
Anti-CD324
Anti-E-Cadherin
Anti-CDHE
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The antibody detects endogenous level of total E-Cadherin protein.
CDH1 (cadherin 1) codes for a transmembrane glycoprotein E-cadherin that is located on human chromosome 16q22.1. It is a tumor suppressor gene, which is also known as Cdh1p/Hct1p, Fizzy-related, Ste9, or Srw1.

免疫原

Peptide sequence around aa. 864-868 (E-W-G-N-R), according to the protein NP_004351.1

生化/生理作用

CDH1 (cadherin 1) helps to conserve the homophilic cell-cell adhesion in epithelial tissues. Inadequate expression of CDH1 results in colon cancer and renal cell carcinoma (RCC).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~135 kDa
species reactivity human, mouse, rat
浓度 1 mg/mL
technique(s) western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (E-W-G-N-R)
NCBI登记号 NM_004360.3
运输 wet ice
储存温度 ?20℃
Gene Information human ... CDH1(999)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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