Anti-CD70 Antibody, clone TAN 1-7

半岛bd体育手机客户端 说明

一般描述

CD70 is an interesting membrane bound cellular factor that acts as a cytokine which binds the receptor CD27. Binding induces the proliferation and co-stimulation of T cells and enhances the generation of cytolytic T-cells. Thus, CD70 plays important roles in T cell adaptive T cell response as well as in innate immunity and is required for the proper activation of the anti-viral adaptive response. CD70 also serves as a regulatory role in early cytokine responses to pathogens through the maintenance of Treg cell survival and function. Recent research also indicates that CD70 expression could be important in autoimmune disease regulation and in treatment of autoimmune diseases such as rheumatoid arthritis. CD70 is expressed on T cells, splenocytes, and thymocytes and it belongs to the TNF family of cellular signaling proteins.

免疫原

Recombinant protein corresponding to the extracellular domain of mouse CD70.
Epitope: Extracellular domain

应用

Flow Cytometry Analysis: 2 ?g of this antibody detected CD70 in mouse bone marrow dendritic cells treated with 2000U/mL GM-CSF and 0.1 ug/mL of LPS.
Functional Blocking Analysis: A representative lot detected CD70 in splenic CD8a+ DCs (Arora, P., et al. (2014). Immunity. 40:105-116).
Anti-CD70 Antibody, clone TAN 1-7 | MABF112 is an antibody against CD70 Antibody for use in Western Blotting, Flow Cytometry.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blotting in mouse spleen tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected CD70 in 10 ?g of mouse spleen tissue lysate.

目标描述

~27 kDa observed

外形

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	rat
抗体形式	purified antibody
antibody product type	primary antibodies
克隆	TAN 1-7, monoclonal
species reactivity	mouse
technique(s)	flow cytometry: suitable western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_035747
UniProt登记号	O55237
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable