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位置: 首页> 品牌> Sigma-Aldrich> Anti-CD4 Antibody (mouse), violetFluor?450, clone RM4-5

Anti-CD4 Antibody (mouse), violetFluor?450, clone RM4-5

品牌
Sigma-Aldrich
货号
MABF575
规格纯度
clone RM4-5, 0.2 mg/mL, violetFluor?
价格
1415.25 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-CD4 Antibody (mouse), violetFluor ?450, clone RM4-5
T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, CD4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will “compete” for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.

免疫原

Immunogen information for this antibody is proprietary information.

应用

This rat monoclonal antibody Anti-CD4 (mouse), violetFluor 450, clone RM4-5 validated for use in IP, IHC, Immunofluorescence & Flow Cytometry for the detection of CD4.
Research Category
Inflammation & Immunology

质量

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 ?g of this antibody detected CD4 in one million C57Bl/6 splenocytes.

外形

Size Exclusion Chromatography
Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

法律信息

violetFluor is a registered trademark of Tonbo Biotechnologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
偶联物 violetFluor?450
抗体形式 purified antibody
antibody product type primary antibodies
克隆 RM4-5, monoclonal
species reactivity mouse
包装 antibody small pack of 25 μg
manufacturer/tradename violetFluor?
浓度 0.2 mg/mL
technique(s) flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型 IgG2aκ
UniProt登记号 P06332
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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