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位置: 首页> 品牌> Sigma-Aldrich> Anti-CD4 Antibody (mouse), FITC, clone GK1.5

Anti-CD4 Antibody (mouse), FITC, clone GK1.5

品牌
Sigma-Aldrich
货号
MABF412
规格纯度
clone GK1.5, 0.5 mg/mL, from rat
价格
3841.74 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-CD4 Antibody (mouse), FITC, clone GK1.5
CD44 antigen, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Hermes antigen, Hyaluronate receptor, Lymphocyte antigen 24, Ly-24, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD44
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will “compete” for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.

免疫原

Immunogen information for this antibody is proprietary information.

应用

This Rat Monoclonal Antibody Anti-CD4 (mouse), FITC, clone GK1.5, Cat. No. MABF412 is validated for use in IP, IHC, FC for the detection of CD4.
Research Category
Inflammation & Immunology

外形

Size Exclusion Chromatography
Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.44

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
偶联物 FITC conjugate
抗体形式 purified antibody
antibody product type primary antibodies
克隆 GK1.5, monoclonal
species reactivity mouse
浓度 0.5 mg/mL
technique(s) flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型 IgG2bκ
UniProt登记号 P15379
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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