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位置: 首页> 品牌> Sigma-Aldrich> Anti-CD28 Antibody (human), FITC, clone CD28.2

Anti-CD28 Antibody (human), FITC, clone CD28.2

品牌
Sigma-Aldrich
货号
MABF560
规格纯度
clone CD28.2, from mouse
价格
2332.34 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-CD28 Antibody (human), FITC, clone CD28.2
T-cell-specific surface glycoprotein CD28, TP44, CD antigen CD28
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICCOS and BTLA.The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4+ T cells and CD8+ T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo. This antibody is also reported to be cross-reactive with several non-human species, including Baboon, Chimpanzee, Cynomolgus, and Rhesus.

免疫原

Immunogen information for this antibody is proprietary information.

应用

This mouse monoclonal antibody Anti-CD28 (human), FITC, clone CD28.2 validated for use in IP, IHC & Flow Cytometry for the detection of CD28.
Research Category
Inflammation & Immunology

质量

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.5 ?g of this antibody detected CD28 in one million human peripheral blood lymphocytes.

外形

Size Exclusion Chromatography
Purified Mouse Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.44

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 FITC conjugate
抗体形式 purified antibody
antibody product type primary antibodies
克隆 CD28.2, monoclonal
species reactivity human
包装 pkg of 5 μL (0.5 μg/test)
technique(s) flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型 IgG1κ
UniProt登记号 P10747
运输 wet ice
Gene Information human ... CD28(940)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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