您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-CD279 (PD-1) Antibody (mouse), PE, clone J43.1

Anti-CD279 (PD-1) Antibody (mouse), PE, clone J43.1

品牌
Sigma-Aldrich
货号
MABF556
规格纯度
clone J43.1, 0.2 mg/mL, from hamster(Armenian)
价格
1415.25 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-CD279 (PD-1) Antibody (mouse), PE, clone J43.1
Programmed cell death protein 1, Protein PD-1, mPD-1, CD279
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with “B7” ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.The J43.1 antibody may be used as a marker for PD-1 expression, and is commonly used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo.

免疫原

Immunogen information for this antibody is proprietary information.

应用

This armenian hamster monoclonal antibody Anti-CD279 (PD-1) (mouse), PE, clone J43.1 validated for use in IP, IHC & Flow Cytometry for the detection of CD279 (PD-1).
Research Category
Inflammation & Immunology

质量

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.5 ?g of this antibody detected CD279 (PD-1) in one million C57Bl/6 splenocytes.

外形

Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Size Exclusion Chromatography

储存及稳定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 hamster (Armenian)
偶联物 PE
抗体形式 purified antibody
antibody product type primary antibodies
克隆 J43.1, monoclonal
species reactivity mouse
包装 antibody small pack of 25 μg
浓度 0.2 mg/mL
technique(s) flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型 IgG
UniProt登记号 Q02242
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map