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位置: 首页> 品牌> Sigma-Aldrich> Anti-Caspase-4, clone 17D9 Antibody

Anti-Caspase-4, clone 17D9 Antibody

品牌
Sigma-Aldrich
货号
MABF265
规格纯度
clone 17D9, from rat
价格
4848.93 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-Caspase-4, clone 17D9 Antibody
Caspase-4, CASP-4, Caspase-11, CASP-11, Protease ICH-3, .Caspase-4 subunit p10, Caspase-4 subunit p20
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Caspase-4 (CASP-4), also known as Caspase-11 (CASP-11), or Protease ICH-3, and encoded by the gene names Casp4, Casp11, Caspl, and Ich3, is a member of the peptidase C14A family and might be involved in ER-stress induced apoptosis. Caspase-4 protein has been shown to cleave Caspase-1 and might be involved in the activation cascade of caspases responsible for apoptosis execution. Caspase-4 promotes IL-1 beta processing by ICE, and therefore may also play a role in inflammatory responses. Caspase-4 has been indicated to interact with TMEM214, in the process of ER membrane localization. Additionally, Caspase-4 is a heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The two subunits are derived by an autocatalytic mechanism, from the precursor sequence. Recent studies have shown that the activity of Caspase-4 is increased 30-fold by endotoxins (LPS). Other studies have indicated that Caspase-4 is induced by ER stress in a DDIT3/CHOP-dependent manner. Caspase-4 is expressed mostly in lung and spleen, and less in liver, skeletal muscle, kidney and testis.

免疫原

Corresponding to mouse Caspase-4.

应用

Immunoprecipitation Analysis: A representative lot immunoprecipitated Caspase-4 in ischemia induced mouse brains (Kang, S., et al. (2000) JCB. 149(3):613-622).
Immunohistochemistry Analysis: A representative lot detected Caspase-4 in wildtype and ischemic mouse brains (Kang, S., et al. (2000) JCB. 149(3):613-622).
Anti-Caspase-4, clone 17D9 is an antibody against Caspase-4 for use in WB, IP, IH.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blotting in bacterial J53 treated macrophage cell lysate.

Western Blotting Analysis: 2.0 ?g/mL of this antibody detected Caspase-4 in 10 ?g of bacterial J53 treated macrophage cell lysate.

目标描述

~48 and 38 kDa observed

外形

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 17D9, monoclonal
species reactivity human, mouse
technique(s) immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型 IgG2aκ
NCBI登记号 NP_031635
UniProt登记号 P70343
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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