Anti-CA3 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Anti-CA3 Antibody detects endogenous levels of total CA3 protein.
Carbonic anhydrase III (CA3) is a member of a multi-gene CA family that encodes carbonic anhydrase isozymes namely Car3 and CAIII. The expression of isozymes has been shown to abundantly increase during muscle aging and is relatively muscle specific. It exhibits a fibre type-specific expression pattern.

免疫原

The antiserum was produced against synthesized peptide derived from human CA3.

Immunogen Range:141-190

应用

Anti-CA3 antibody produced in rabbit is suitable for indirect ELISA and western blot applications.

生化/生理作用

Carbonic anhydrase III (CA3) may act as a new biomarker of sarcopenia. Higher CA levels indicate an increased demand of CO₂removal in senescent muscle and the age-related fibre type shifts to slower-contracting muscles during human aging. CA3 is found to be associated with rheumatoid arthritis. It is specifically insufficient in the skeletal muscle of patients suffering from Myasthenia gravis (MG) (an autoimmune disease mainly mediated by antibodies against acetylcholine receptor). CA3 possesses low carbon dioxide hydratase activity, resistance to the CA inhibitor acetazolamide unlike the other members of the CA family.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen 29 kDa
species reactivity	human, mouse, rat
浓度	~1 mg/mL
technique(s)	ELISA: 1:20000 western blot: 1:500-1:1000
NCBI登记号	P07451
运输	wet ice
储存温度	?20℃
Gene Information	human ... CAH3(761)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable