Anti-Bst2 Antibody

半岛bd体育手机客户端 说明

一般描述

Bone marrow stromal cell antigen 2 (BST-2, Bst2), also known as CD317, and HM1.24 antigen, is an IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian viruses by directly tethering nascent virions to the membranes of infected cells. Bst2 has been shown to interact with various viruses, including: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Bst2 may inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Additionally, it is implied to interact with LILRA4/ILT7, which results in providing negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. This activity suggests that Bst2 can provide a potential therapeutic strategy for the treatment of HIV/AIDS. Bst2 may play a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells

特异性

This antibody recognizes the N-terminus of Bst2.

免疫原

KLH-conjugated linear peptide corresponding to the N-terminus of mouse Bst2.
Epitope: N-terminus

应用

Research Sub Category
Immunological Signaling
Detect Bone marrow stromal antigen 2 using this rabbit polyclonal antibody, Anti-Bst2 Antibody validated for use in western blotting.
Western Blotting Analysis: 2 ?g/mL from a representative lot detected Bst2 in 15 ?g of Daudi cell lysate.
Research Category
Inflammation & Immunology

质量

Evaluated by Immunohistochemistry in human placenta tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Bst2 in human placenta tissue.

目标描述

~22 kDa observed. Uncharacterized bands may appear in some lysate(s).

联系

Replaces: MABF201

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human placenta tissue

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
technique(s)	western blot: suitable
UniProt登记号	Q8R2Q8
运输	wet ice

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable