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位置: 首页> 品牌> Sigma-Aldrich> Anti-Birc7/LIVIN Antibody

Anti-Birc7/LIVIN Antibody

品牌
Sigma-Aldrich
货号
ABC97
规格纯度
from rabbit, purified by affinity chromatography
价格
5512.56 *本价格含增值税费
促销
服务
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数量
- +
半岛bd体育手机客户端 名称:
Anti-Birc7/LIVIN Antibody
Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, KIAP, Livin, Melanoma inhibitor of apoptosis protein, ML-IAP, RING finger protein 50
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Livin, also known as “baculoviral IAP repeat-containing protein 7” (Birc7) and "KIAP," is a member of the IAP (inhibitors of apoptosis) family of proteins characterized by highly conserved baculoviral IAP repeats (BIR). In addition, Livin contains one RING-type zinc finger domain. Livin has been detected in the heart, placental, lung, lymph node, ovary, spleen, and in various types of solid tumors. It may suppress apoptosis induced by TNF, viral infection, drugs, and growth factor withdrawal, by inhibiting caspase activity (caspase 3, 7, and 9) and activating a MAPK/JUN pathway. Paradoxically, Livin may also function as a pro-apoptic factor in a truncated form (tLivin) that is cleaved by caspase 3 from the full-length protein. The pro-apoptotic effects of Livin may depend on its RING domain. Livin may play a role in non-Hodgkin lymphoma.

特异性

This antibody recognizes the BIR repeat region of Birc7/LIVIN.
Other homologies: Rat, Mouse, and Bovine (93% sequence homology).

免疫原

Epitope: BIR repeat region
KLH-conjugated linear peptide corresponding to the BIR repeat region of human Birc7/LIVIN.

应用

Research Sub Category
Apoptosis - Additional
Anti-Birc7/LIVIN detects levels of Birc7/LIVIN proteins & has been published & validated for use in WB.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blot in human spleen tissue lysate.

Western Blot Analysis: 1 ?g/mL of this antibody detected Birc7/LIVIN in 10 ?g of human spleen tissue lysate.

目标描述

~39 kDa, ~32 kDa observed. Two isoforms at 32 kDa and 30 kDa are known to exist. This protein has been observed at ~39 kDa (alpha) and ~37 kDa (beta) due to post translational modification (Nachmias, B., et al. (2007). Apoptosis. 12(7):1129-1142.).

外形

Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human spleen tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
species reactivity (predicted by homology) rhesus macaque (based on 100% sequence homology)
technique(s) western blot: suitable
NCBI登记号 NP_647478
UniProt登记号 Q96CA5
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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