Anti-Beta-mannosidase Antibody, clone 1B3.1

半岛bd体育手机客户端 说明

一般描述

Beta-mannosidase, also known as Lysosomal beta A mannosidase or Mannanase, or Mannase, and encoded by the gene MANBA/MANB1, is an exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. Beta-mannosidase is localized to the lysosome. Beta-mannosidase is expressed in many cell types including fibroblasts, neutrophils and even neurons and glia. Defects in Beta-mannosidase may be associated with a mild disorder that affects peripheral and central nervous system myelin health and is called Mannosidoisis beta A. It is a lysosomal storage disorder that results in a mixture of clinical features from mental retardation, hearing loss and speech activities.

免疫原

KLH-conjugated linear peptide corresponding to human Beta-mannosidase.

应用

Research Sub Category
Signaling Neuroscience
Research Category
Neuroscience
Anti-Beta-mannosidase Antibody, clone 1B3.1 is a highly specific mouse monoclonal antibody, that targets Mannosidase & has been tested in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Beta-mannosidase in human cerebral cortex tissue.

质量

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 0.2 ?g/mL of this antibody detected Beta-mannosidase in 10 ?g of HepG2 cell lysate.

目标描述

~80 kDa observed. The calculated molecular weight of this protein is 100 kDa However, this protein undergoes post-translational modification, and may be observed at ~110 kDa, ~100 kDa, ~91 kDa, ~86 kDa, ~84 kDa, and ~75 kDa (Sopher, B. L., et al. (1993). Biochem J. 289(Pt 2):343-347.).

外形

Format: Purified
Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	1B3.1, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_005899
UniProt登记号	O00462
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable