Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody

半岛bd体育手机客户端 说明

一般描述

Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.

免疫原

KLH-conjugated linear peptide corresponding to human BAG3.

应用

Research Sub Category
Apoptosis - Additional
Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected BAG3 in human cardiac and renal tissues.
Research Category
Apoptosis & Cancer
Detect BAG family molecular chaperone regulator 3 (BAG3) using this Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody validated for use in Western Blotting, IHC(P).

质量

Evaluated by Western Blot in DU145 cell lysate.

Western Blot Analysis: 0.5 ?g/mL of this antibody detected BAG3 in 10 ?g of DU145 cell lysate.

目标描述

~74/40 kDa observed. An uncharacterized band may appear at ~65 kDa in some lysates.

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
DU145 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
species reactivity (predicted by homology)	rhesus macaque (based on 100% sequence homology), canine (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology)
technique(s)	immunohistochemistry: suitable (paraffin) western blot: suitable
NCBI登记号	NP_004272
UniProt登记号	O95817
运输	wet ice
Gene Information	human ... BAG3(9531)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable