Anti-ATP6V1H antibody produced in rabbit

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一般描述

The gene ATP6V1H (ATPase H⁺transporting V₁subunit H) is mapped to human chromosome 8q11.2. It encodes a lysosomal protein with a molar mass of 50/57kDa. This protein forms the subunit of vacuolar ATPase (V-ATPase), a protein widely found in various eukaryotic endomembrane organelles. V-ATPase is a member of the rotary ATPase family, the members of which use rotary motor mechanisms for the transportation of ions across membranes. V-ATPase has two domains, V₀and V₁that function in transportation of proton and hydrolysis of ATP, respectively. The V₁domain is composed of eight subunits, A-H.

免疫原

The antiserum was produced against synthesized peptide derived from human ATP6V1H.

Immunogen Range:341-390

生化/生理作用

The gene ATP6V1H (ATPase H⁺transporting V₁subunit H) encodes the regulatory subunit H of the V₁domain of V-ATPase. This multisubunit complex of V-ATPase functions in the acidification of intracellular compartments via the energy generated from ATP hydrolysis. Therefore, V-ATPase participates in receptor-mediated endocytosis, intracellular trafficking processes and degradation of proteins. Down-regulation of ATP6V1H gene in human pancreatic islets has been associated with type 2 diabetes. Its expression is negatively associated with HbA1c levels. It has a positive regulatory effect on glucose-stimulated insulin secretion.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

基本信息

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