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位置: 首页> 品牌> Sigma-Aldrich> ANTI-APCDD1(N-TERMINAL) antibody produced in rabbit

ANTI-APCDD1(N-TERMINAL) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1307046
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
6098.42 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
ANTI-APCDD1(N-TERMINAL) antibody produced in rabbit
APCDD1
Adenomatosis polyposis coli down-regulated 1 protein
DRAPC1
Protein APCDD1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Adenomatosis polyposis coli down-regulated 1 (APCDD1) encodes a membrane bound glycoprotein. Apcdd1 is predominantly expressed in epidermal and dermal compartments of human hair follicles. In human chromosome, the gene APCDD1 is localized on 18p11.22.

生化/生理作用

Adenomatosis polyposis coli down-regulated 1 (APCDD1) inhibits wnt (wingless/integrated) signalling and promotes human hair growth. Mutations in APCDD1 results in a rare autosomal dominant hereditary hypotrichosis, which is characterized by hair loss due to hair follicle miniaturization. APCDD1 is directly regulated by β-catenin/T-cell factor 4 (TCF4). The high expression of Apcdd1 in colon cancer cells promotes its proliferation. APCDD1 is essential for adipocyte differentiation. Downregulation of APCDD1 in diet induced obesity impairs adipocyte differentiation and causes obesity related metabolic diseases.

外形

Supplied in PBS with 0.09% (W/V) sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 58797 Da
species reactivity human
technique(s) immunohistochemistry: 1:10-1:50
western blot: 1:1000
NCBI登记号 NP_694545.1
UniProt登记号 Q8J025
运输 wet ice
储存温度 ?20℃
Gene Information human ... APCDD1(147495)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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