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Anti-APC8 Antibody

品牌
Sigma-Aldrich
货号
ABE797
规格纯度
from rabbit, purified by affinity chromatography
价格
5512.56 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-APC8 Antibody
Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, APC8, Cyclosome subunit 8
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cell division cycle protein 23 homolog, also known as Anaphase-promoting complex subunit 8 (APC8) or Cyclosome subunit 8, and encoded by the gene name CDC23 or ANAPC8, is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.

免疫原

KLH-conjugated synthetic peptide corresponding to the center region of human APC8.
Epitope: center region

应用

Immunocytochemistry Analysis: 5 μg/mL from a representative lot detected APC8 in K562 cells.
Research Sub Category
Cell Cycle, DNA Replication & Repair
Detect APC8 using this Anti-APC8 Antibody validated for use in western blotting & ICC.
Research Category
Epigenetics & Nuclear Function

质量

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected APC8 in K562 cell lysate.

目标描述

~55 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 3 isoforms produced by alternative splicing at ~17 kDa, ~56 kDa, and ~69 kDa

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) immunocytochemistry: suitable
western blot: suitable
UniProt登记号 Q9UJX2
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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