半岛bd体育手机客户端 说明
一般描述
The ANGPT2 (angiopoietin 2) gene is mapped to 8p23.1. The encoded protein belongs to the family of angiogenic factors.
免疫原
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 515 of Angiopoietin 2 according to NP_001138
应用
Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
生化/生理作用
The protein encoded by the ANGPT2 (angiopoietin 2) gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq]Ang-2 influences vascular stability by acting as a competitive antagonist of Ang-1. The agonistic function of Ang-2 is essential for lymphatic vascular formation. Overexpression of ANGPT2 is observed in liver cancer and cirrhosis and it induces cell proliferation. It also serves as an important biomarker for liver cancer. Ang-2 stimulates angiogenesis contributing to pathogenesis and progression of a number of chronic liver diseases.
特点和优势
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外形
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human, mouse |
| technique(s) | immunohistochemistry: suitable western blot: 500-3000 |
| NCBI登记号 | NP_001138 |
| UniProt登记号 | O15123 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... ANGPT2(285) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H317 - H412 |
| 预防措施声明 | P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313 |
| 危险分类 | Aquatic Chronic 3 - Skin Sens. 1 |
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
Sigma-Aldrich
m.cnreagent.com
