半岛bd体育手机客户端 说明
一般描述
Akkermansia muciniphilais a Gram negative, oval shaped, non-motile, non-spore forming strictly anaerobic bacteria.1A. muciniphilacolonized in the mucus layer of the human intestine niche.A muciniphilainhabits the gastrointestinal tracts of most of healthy adults and represents 1-4% of the total fecal microbiota starting from early life.2 It is one of the top 20 most abundant species detectable in the human gut.3 It was found thatA. muciniphilaabundance in the gut was correlated to a healthy intestine and inversely correlated to many disease conditions.2 In comparison to healthy controls,A. muciniphilalevels were low in intestinal disorders, such inflammatory bowel disease IBD, but also in other conditions, such as autism, atopy, and obesity.2,5-8 Therefore,A. muciniphilawas suggested to serve as a marker of healthy intestine.
In addition, goring research identifiedA. muciniphilaas a promising potential probiotic that can be administrated for the treatment of diseases such as, colitis, metabolic syndromes, immune diseases and cancer. However more research is needed to verify the safety of oral administration ofA. muciniphilain humans.3
特异性
Anti-Akkermansia muciniphila antibody recognizesA. muciniphilalysate and whole dead bacteria.
生化/生理作用
A. muciniphilais able to degrade mucin, a key mucus component, using the enzymes sialidase and fucosidase, and utilize it as a source of carbon and nitrogen.2 Mucin degradation byA. muciniphilaresults in the production of short-chain fatty acids (SCFA), that become available metabolites to the host and also can stimulate the host immune system. Moreover, SCFA promotes the growth and metabolic activity of mucus- associated gut microbiota preventing the pathogenic bacteria from reaching the intestinal cells.4
外形
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
储存及稳定性
For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses,in vitrodiagnostic uses,ex vivoorin vivotherapeutic uses or any type of consumption or application to humans or animals.
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 形式 | liquid |
| species reactivity | (Akkermancia muciniphila) |
| 包装 | pkg of 100 μL pkg of 25 μL |
| 浓度 | ~1 mg/mL |
| technique(s) | immunoblotting: 1:500-1:1000 usingAkkermansia muciniphilalysate |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
