Anti-AIMP1 (N-terminal) antibody produced in goat

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一般描述

AIMP1 (aminoacyl-tRNA synthetase-interacting multifunctional protein 1)/endothelial monocyte activating polypeptide-II (EMAP-II) is also termed as p43. It is present in the nucleus of normal and healthy chondrocytes. EMAP-II is a multifunctional cytokine. It is located on human chromosome 4q24.

免疫原

Peptide with sequence NNDAVLKRLEQK-C, from the N-terminal region of the protein sequence according to NP_004748.2; NP_001135888.1

生化/生理作用

AIMP1 actively participates in inflammation, angiogenesis, wound healing and glucose homeostasis. It blocks SMAD2 (SMAD family member 2) and SMAD3 (SMAD family member 3) phosphorylation and downregulates TGF-β (transforming growth factor beta 1) signaling. Endothelial monocyte activating polypeptide-II (EMAP-II) possesses proinflammatory and anti angiogenic activity, that plays a vital role in the progression of endothelial dysfunction and atherosclerosis.

特点和优势

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外形

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

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