Anti-ADORA2A antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

Adenosine A2A receptor (ADORA2A) or A2AR is a heptaspanning-membrane-receptor (HSMR) expressed majorly in the basal ganglia especially in the γ-aminobutyric acid (GABA)ergic striatopallidal neurons. The ADORA2A gene is mapped to human chromosome 22q11.23.

免疫原

ADORA2A (NP_000666, 1 a.a. ~ 412 a.a) full-length human protein.

Sequence
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

生化/生理作用

Mutation in the adenosine A2A receptor (ADORA2A) gene is implicated in the pathophysiology of autism spectrum disorders (ASDs) and panic disorder. A2AR mediates the release of neurotransmitters in γ-aminobutyric acid (GABA)ergic neurons in rats.
ADORA2A activation leads to increased levels of cAMP within the cell. It is known to inhibit the inflammatory action of neutrophil. Abnormal expression of ADORA2A (adenosine A2a receptor) might be involved in the development of glioma. Also, downregulation of the gene might promote the susceptibility towards tumor-associated epilepsy.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
species reactivity	human
technique(s)	western blot: 1 μg/mL
NCBI登记号	NM_000675
UniProt登记号	P29274
运输	dry ice
储存温度	?20℃
Gene Information	human ... ADORA2A(135)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable