Anti-ADE2 Antibody/SAICAR synthetase

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一般描述

Multifunctional protein ADE2, which is encoded by the gene name PAICS, ADE2, AIRC, PAIS, is a member of the SAICAR synthetase family and the AIR carboxylase family. Multifunctional protein ADE2 includes the following two domains: Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase), and Phosphoribosylaminoimidazole carboxylase (AIR carboxylase/ AIRC). ADE2 is a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. ADE2 is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for ADE2. ADE2/ PAICS (phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase) is a protein-coding gene. Diseases associated with ADE2 include androgen insensitivity syndrome, and pseudohermaphroditism, and among its related super-pathways are Metabolic pathways and Purine metabolism.

免疫原

Epitope: SAICAR synthetase
KLH-conjugated linear peptide corresponding to human ADE2/SAICAR synthetase.

应用

This Anti-ADE2 antibody is validated for use in Western Blotting for the detection of ADE2.

质量

Evaluated by Western Blotting in TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate.

Western Blotting Analysis: 2.0 ?g/mL of this antibody detected ADE2/SAICAR synthetase in 10 ?g of TF-1, K562, HL-60, THP-1, Jurkat, and MOLT-4 cell lysate.

目标描述

~47 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Affinity purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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