Anti-ADAR2 Antibody, clone 1.3.1

半岛bd体育手机客户端 说明

一般描述

Double-stranded RNA-specific editase 1, or RNA-editing deaminase 1, or RNA-editing enzyme 1, or dsRNA adensine deaminase, and encoded by the human gene ADARB1/ ADAR2, DRADA2, RED1 is an enzyme that catalyzes the deamination of adenosine in dsRNA to inosine in a step called A to I RNA editing. This editing alters gene expression by changing codon usage and splicing sites as well as altering general RNA stability. So far the enzyme has been shown to edit and destabilize cancer associated genes as well as functional neurotransmitter receptors, and channel proteins. Interestingly, its activity appears to inhibit cell proliferation and migration in some cells and promote exocytosis and metabolism in others, likely to do differential affects on particular important mRNAs. Highly expressed in brain, heart with lower expression in lung, kidney and liver tissues. Interestingly RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen.

免疫原

GST-tagged recombinant protein corresponding to the C-terminus of human ADAR2.
Epitope: C-terminus

应用

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Anti-ADAR2 Antibody, clone 1.3.1 detects level of ADAR2 & has been published & validated for use in ADAR2.

质量

Evaluated by Western Blotting in HeLa nuclear extract.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected ADAR2 in 10 ?g of HeLa nuclear extract.

目标描述

~80 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	1.3.1, monoclonal
species reactivity	human
technique(s)	western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_001103
UniProt登记号	P78563
运输	wet ice
Gene Information	human ... ADARB1(104)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable