Anti-ADAR1 (C-terminal) antibody produced in rabbit

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一般描述

Adenosine deaminase that acts in RNA (ADAR) 1 belongs to ADAR family. It is expressed in most of the human tissues. ADAR1 has several isoforms which include the full length ADAR1 (150 kDa) and two functionally active short isoforms (80 and 110 kDa).
The ADAR1 gene is mapped on the human chromosome at 1q21.3.

特异性

Anti-ADAR1 (C-terminal) recognizes human ADAR1.

免疫原

synthetic peptide corresponding to a sequence at the C-terminal region of human ADAR1, conjugated to KLH. The corresponding sequence is identical in rat, bovine, pig, dog and monkey and differs by one amino acid in mouse.

应用

Anti-ADAR1 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

生化/生理作用

Adenosine deaminase that acts in RNA (ADAR) facilitates RNA editing by catalyzing the hydrolytic deamination of adenosine (A) to inosine (I) in double-stranded (ds). ADAR1 plays critical roles in differentiating cells of embryo and adult tissues, facilitating cell survival and permitting their further differentiation and maturation. Its role in embryonic development is especially demonstrated within the hematopoietic lineage as well as in adult hematopoietic progenitor cells (HPCs). In addition, ADAR1 regulates hematopoietic stem cell maintenance and suppresses interferon signaling that may protect organisms from the harmful effects of interferon activation leading to various pathological conditions, such as chronic inflammation, autoimmune disorders, and cancer.

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8 ℃ for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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