半岛bd体育手机客户端 说明
一般描述
The adhesion and degranulation adaptor protein (ADAP) acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. ADAP modulates the expression of interleukin-2 (IL-2) and it is suggested to be involved in platelet activation. Additionally ADAP is shown to prevent the degradation of SKAP1 and SKAP2 and may play a role in linking T-cell signaling to the remodeling of the actin cytoskeleton. ADAP is expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. At least two isoforms of ADAP are known to exist.
特异性
This antibody recognizes the C-terminus of ADAP.
免疫原
KLH-conjugated linear peptide corresponding to the C-terminus of human ADAP.
Epitope: C-terminus
应用
Research Category
Cell Structure
Detect ADAP using this rabbit polyclonal antibody, Anti-ADAP Antibody validated for use in western blotting & ICC.
Immunocytochemistry Analysis: 10 ?g/mL from a representative lot detected ADAP in K562 cells.
Research Sub Category
Adhesion (CAMs)
质量
Evaluated by Western Blotting in K562 cell lysate.
Western Blotting Analysis: 1 ?g/mL of this antibody detected ADAP in 15 ?g of K562 cell lysate.
目标描述
~130 kDa observed. Uncharacterized bands may appear in some lysates. Uniprot describes 2 isoforms at ~85 kDa and ~91 kDa
外形
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
K562 cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | human |
technique(s) | immunocytochemistry: suitable western blot: suitable |
UniProt登记号 | O15117 |
运输 | wet ice |
Gene Information | human ... FYB(2533) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich