您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-ABCA1 Antibody, clone MABI98-7

Anti-ABCA1 Antibody, clone MABI98-7

品牌
Sigma-Aldrich
货号
MABN893
规格纯度
clone MAB198-7, from rat
价格
5520.38 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-ABCA1 Antibody, clone MABI98-7
ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, ATP-binding cassette 1, ABCA 1, ABCA-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

ATP-binding cassette sub-family A member 1, also known as ATP-binding cassette transporter 1 (ABC-1), or ATP-binding cassette 1, and encoded by the gene name Abca1 or Abc1, is a cAMP-dependent and sulfonylurea-sensitive anion transporter. ABCA1 is a member of the ABC transporter superfamily and the ABCA family. ABCA1 is a key gatekeeper influencing intracellular cholesterol transport. ABCA1 has two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain, and may act as a multifunctional polypeptide. ABCA1 has been shown to be down-regulated by endotoxins (LPS) or cytokines (TNF and IL-1) in J774 macrophages. The down-regulation by endotoxin in macrophages is not likely to be mediated by the liver X receptor/retinoic X receptor (LXR/RXR). ABCA1 interacts with MEGF10 and is widely expressed in adult tissues, with the highest levels found in uterus and pregnant uterus. Mutations in the ABCA1 gene are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking.

免疫原

Epitope: Immunogen is near C-terminal.
Linear peptide corresponding to the C-terminus of Mouse ABCA1.

应用

Western Blotting Analysis: A representative lot of MABN893 deteted ABCA1 in lysate of WT mouse brain and demonstrated a loss of signal in lysates of ABCA1 knock out adult mouse brain (Hu et al., 2008. J Lipid Res. 2008 Feb;49(2):386-93.)
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected ABCA1 in human cerebral cortex, thalamus, and kidney tissues.
Produced in collaboration with MAB Institute, Inc.
This Anti-ABCA1 antibody is validated for use in WB, IH for the detection of ABCA1.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters

质量

Evaluated by Western Blotting in Calyculin and Okadaic Acid treated NIH-3T3 cell lysate.

Western Blotting Analysis: A 1 ?g/mL diultion of this antibody detected ABCA1 in 10 ?g of Calyculin and Okadaic Acid treated NIH-3T3 cell lysate.

目标描述

~254 kDa observed

外形

Format: Purified
Purified rat monoclonal IgG2aκ in buffer containing PBS with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 MAB198-7, monoclonal
species reactivity human, mouse
technique(s) immunohistochemistry: suitable
western blot: suitable
同位素/亚型 IgG2aκ
NCBI登记号 NP_038482
UniProt登记号 P41233
运输 dry ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map