Anti-SND1 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

The SND1 protein is a part of the RNA-induced silencing complex (RISC). It is highly conserved from yeast to human.
Staphylococcal nuclease and tudor domain containing 1 (SND1), also called as Tudor-SN, is encoded by the gene mapped to human chromosome 7q32.1. The encoded protein acts as an important constituent of RNA-induced silencing complex (RISC). SND1 is characterized with an five repeated staphylococcal nuclease homology domains and a Tudor-homology domain involved in interaction of nucleic acids and proteins, respectively.

特异性

Anti-SND1 recognizes human, rat and mouse SND1.

免疫原

peptide corresponding to an internal region of human SND1, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and rat.

应用

Anti-SND1 antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

生化/生理作用

Staphylococcal nuclease and tudor domain containing 1 (SND1) interacts with RNA in some sequence-specific manner and regulates the gene expression at both transcriptional and posttranscriptional levels. The encoded protein plays a key role in gene transcription and mRNA metabolism. Additionally, it is also implicated in maintenance of cellular cholesterol distribution and homeostasis in hepatoma cells. SND1 facilitates various RNA functions such as, RNA maturation, spliceosome assembly,pre-mRNA splicing, RNA stability and RNA editing. It is also involved in RNA interference,microRNA processing, response to environmental and metabolic stressors and lipoprotein lipid secretion. Overexpression of the gene has been observed in human colon cancers and hepatocellular carcinoma cells.
SND1 protein plays a vital role in the degradation of hyper-edited inosine containing miRNA precursors. It also controls miRNA processing and expression through RNA editing by adenosine deaminase acting on RNA (ADAR).

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8℃ for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen ~102 kDa
species reactivity	mouse, human, rat
浓度	~1.0 mg/mL
technique(s)	immunoprecipitation (IP): 1-2 μg using lysates of rat NRK cells. indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa cells. western blot: 0.25-0.5 μg/mL using whole extracts of mouse NIH-3T3 cells.
UniProt登记号	Q7KZF4
运输	dry ice
储存温度	?20℃
Gene Information	human ... SND1(27044) mouse ... snd1(56463) rat ... snd1(64635)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable