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Anti-Caspase 8 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700197
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Caspase 8 antibody produced in rabbit
CAP4
Casp-8
Caspase 8
FLICE
Caspase-8
ALPS2B
MACH
CASP8
Mch5
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-479 of human Caspase-8 (NP_001073593.1).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 25-32
45- 61
species reactivity human, mouse, rat
浓度 2.21 mg/ml
technique(s) immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000
UniProt登记号 Q14790
运输 wet ice
储存温度 ?20℃
Gene Information human ... CASP8(841)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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