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4EBP1, His tagged human

4EBP1,His 标记 人

品牌
Sigma-Aldrich
CAS
185703-54-2
货号
SRP5162
规格纯度
recombinant, expressed in baculovirus infectedSf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
价格
4311.28 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
185703-54-2
4EBP1, His tagged human
MGC4316
BP-1
EIF4EBP1
PHAS-I
4EBP1,His 标记 人
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Eukaryotic translation initiation factor 4E binding protein 1 (E1F4EBP1) is part of the translation repressor protein family. The gene encoding it is localized on human chromosome 8p11-p12.

生化/生理作用

Eukaryotic translation initiation factor 4E binding protein 1 (E1F4EBP1) is involved in protein synthesis, cell growth and survival. In the unphosphorylated form, it suppresses the translation initiation of capped mRNAs, whereas in phosphorylated form, it increases translation initiation. Phosphorylation of E1F4EBP1 releases it from eukaryotic translation initiation factor 4E (eIF4E) and this results in cap-dependent translation. The protein is also involved in tumorigenesis and the gene is overexpressed in various carcinomas. It is also a substrate for mTORC1 (mammalian target of rapamycin complex 1). In non-phosphorylated conditions, E1F4EBP1 interacts with p21 (cyclin-dependent kinase inhibitor) and enhances destabilization of p21.

外形

Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

制备说明

after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in baculovirus infectedSf9 cells
测定 ≥70% (SDS-PAGE)
形式 buffered aqueous glycerol solution
分子量 ~18 kDa
NCBI登记号 NM_004095
application(s) cell analysis
运输 dry ice
储存温度 ?70℃
Gene Information human ... EIF4EBP1(1978)

安全信息

象形图 GHS07GHS08
警示用语: Danger
危险声明 H315 - H319 - H360D
预防措施声明 P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类 Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 1

Sigma-Aldrich

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