VAP-1 human

半岛bd体育手机客户端 说明

一般描述

VAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaquinone oxidase family. Recombinant VAP-1 is a mixture of monomeric and disulfide linked homodimeric forms of a 737 amino acid polypeptide corresponding to amino acids 27 to 763 of the VAP-1 precursor. The gene AOC3 (amine oxidase, copper containing 3) encodes a 170kDa homodimeric sialylated glycoprotein, VAP-1 (vascular adhesion protein-1), that is abundantly expressed in high endothelial venules (HEV) of peripheral lymph nodes. It is expressed in capillaries of non-lymphatic human tissues, such as kidney and heart. It is also expressed on on adipocytes, dendritic cells and smooth muscle cells.

生化/生理作用

The protein VAP-1 (vascular adhesion protein-1) belongs to the group of semicarbazide sensitive amine oxidases (SSAO) that catalyze the formation of reactive oxygen species. It is a unique adhesion molecule that participates in inflammatory leukocyte recruitment in blood vessels. It functions in leukocyte extravasation to inflamed tissues. In the human eye, it has been associated with ocular inflammatory diseases, such as uveitis, age-related macular degeneration, and diabetic retinopathy. Its expression has been observed to be altered in several diseases, such as rheumatoid arthritis, diabetes, and atherosclerosis.

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.8.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed in CHO cells
测定	≥95% (HPLC) ≥95% (SDS-PAGE)
形式	lyophilized
分子量	80.0-90.0 kDa
包装	pkg of 10 μg
杂质	<0.1 EU/μg endotoxin, tested
颜色	white
UniProt登记号	Q16853
运输	wet ice
储存温度	?20℃
Gene Information	human ... AOC3(8639)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable