半岛bd体育手机客户端 说明

一般描述

Vancomycin is a glycopeptide antibiotic, which was initially isolated fromStreptomyces orientalis. It is effective against multidrug-resistant MRSA strain (methicillin-resistantStaphylococcus aureus). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.

应用

Vancomycin hydrochloride may be used-

• for the assessment of the antimicrobial activity of vancomycin hydrochloride againstMycobacterium tuberculosisin nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain ofM. tuberculosisin a fermentor-grown culture adapted to low oxygen conditions
• for the estimation of biomass in a culture of various strains of bacteria
• as a positive control forE. coliandStaphylococcus aureusin antibacterial activity assay.

生化/生理作用

Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP-N-acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme. It is a frequently used antibiotic for the treatment of peritonitis caused by gram-positive bacteria in patients with continuous ambulatory peritoneal dialysis. In patients with cirrhosis, it is used to control portal systemic encephalopathy. Mice withClostridium difficileinfection (CDI) had better clinical outcome when treated with vancomycin as opposed to the outcome on treatment with metronidazole.

包装

10ML

其他说明

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

基本信息

经验(实验)分子式	C66H75Cl2N9O24· xHCl
分子量	1449.25 (free base basis)
NACRES	NA.85

半岛bd体育手机客户端 性质

质量水平	200
生物来源	Streptomyces orientalis
形式	liquid
储存条件	(Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
浓度	100 mg/mL in DMSO
颜色	colorless to faint tan
作用机制	cell wall synthesis | interferes
抗生素抗菌谱	Gram-positive bacteria
储存温度	?20℃

安全信息

象形图
警示用语：	Danger
危险声明	H317 - H334
预防措施声明	P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
危险分类	Resp. Sens. 1 - Skin Sens. 1
储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	188.6 °F - closed cup
闪点(C)	87 ℃ - closed cup