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TIMP-2 human

品牌
Sigma-Aldrich
货号
SRP3174
规格纯度
recombinant, expressed inE. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
价格
4344.85 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
TIMP-2 human
CSC-21K
Tissue Inhibitor of Metalloproteinase 2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an extracellular inhibitor of matrix metalloproteinases (MMPs) including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors. The gene encoding this protein is localized on human chromosome 17q25. Recombinant human TIMP-2 is a 21.8kDa protein containing 194 amino acid residues.

生化/生理作用

Tissue inhibitor of metalloproteinase-2 (TIMP-2), like other protease inhibitors, functions as a key modulator of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through a matrix metalloproteinase (MMP)-independent mechanism inhibiting endothelial cell proliferationin vitro. It demonstrates anti-angiogenic activitiesin vivo. TIMP-2 is a target gene of the microRNA-miR-22.

序列

MCSCSPVHPQ QAFCNADVVI RAKAVSEKEV DSGNDIYGNP IKRIQYEIKQ IKMFKGPEKD IEFIYTAPSS AVCGVSLDVG GKKEYLIAGK AEGDGKMHIT LCDFIVPWDT LSTTQKKSLN HRYQMGCECK ITRCPMIPCY ISSPDECLWM DWVTEKNING HQAKFFACIK RSDGSCAWYR GAAPPKQEFL DIEDP

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥95% (HPLC)
≥95% (SDS-PAGE)
形式 lyophilized
效能 0.5 μg/mL
分子量 21.8 kDa
包装 pkg of 10 μg
technique(s) cell culture | mammalian: suitable
杂质 <0.1 EU/μg endotoxin, tested
颜色 white
UniProt登记号 P16035
运输 wet ice
储存温度 ?20℃
Gene Information human ... TIMP2(7077)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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