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sRANK Ligand from rat

品牌
Sigma-Aldrich
货号
SRP6231
规格纯度
recombinant, expressed inE. coli, ≥98% (SDS-PAGE)
价格
4532.66 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
sRANK Ligand from rat
TRANCE Receptor
ODAR (osteoclast differentiation and activation receptor)
ODFR (osteoclast differentiation factor receptor)
TNFRSF11A
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate na?ve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansive osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).

外形

Sterile filtered through a 0.2 micron filter. Lyophilized from 5 mM Sodium Phosphate, pH 7.6 and 75 mM NaCl.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 rat
重组 expressed inE. coli
测定 ≥98% (SDS-PAGE)
形式 lyophilized powder
分子量 19.4 kDa
包装 pkg of 10 μg
pkg of 50 μg
杂质 <1 EU/μg endotoxin (LAL test)
UniProt登记号 O00300
运输 wet ice
储存温度 ?20℃
Gene Information human ... TNFRSF11(4982)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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