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R-SPONDIN-3 human

品牌
Sigma-Aldrich
货号
SRP3323
规格纯度
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)
价格
4045.4 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
R-SPONDIN-3 human
Roof plate-specific spondin-3
RSPO3
PWTSR
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, ?-catenin. This activity effectively activates and increases the subsequent nuclear signaling of ?-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/?-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions.

生化/生理作用

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues.

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 150 mM NaCl.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in CHO cells
测定 ≥95% (HPLC)
≥95% (SDS-PAGE)
形式 lyophilized
分子量 26.9 kDa
包装 pkg of 20 μg
杂质 endotoxin, tested
UniProt登记号 Q9BXY4
运输 wet ice
储存温度 ?20℃
Gene Information human ... RSPO3(84870)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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