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R-SPONDIN-2 human

品牌
Sigma-Aldrich
货号
SRP3322
规格纯度
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)
价格
4045.4 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
R-SPONDIN-2 human
Roof plate-specific spondin-2
RSPO2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Recombinant human R-Spondin-2 (R-Spo2) is a 24.4kDa protein consisting of 212 amino acid residues. R-Spo2 is encoded by the gene mapped to human chromosome 8q23.1. The encoded protein belongs to the R-spondin family of secreted proteins. Members of RSpo family contain two furin-like cysteine-rich domains at N- terminal end and thrombospondin structural domain and a basic charged C- terminal domain.

生化/生理作用

R-Spondin 2 (R-Spo2) plays a vital role in the activation of canonical Wnt signaling pathway, which is essential for normal morphogenesis of the respiratory tract and limbs. R-Spo2 positively regulates Wnt-dependent mineralization of osteoblasts, myogenic differentiation and hypertrophic myotube formation. R-Spo2 is also involved in skeletal development. Aberration in the expression of RSPO2 causes ossification of the posterior longitudinal ligament of the spine (OPLL), resulted by the altered differentiation of spinal ligament MSCs (mesenchymal stem cells) into chondrocytes. R-Spo2 is associated with various developmental processes, such as myogenesis, craniofacial morphogenesis, keratinocyte proliferation, osteoblast maturation, lung and limb development. R-Spo2 interacts with leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5) and stimulates acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ).

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 150 mM NaCl.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-0.5 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in CHO cells
测定 ≥95% (HPLC)
≥95% (SDS-PAGE)
形式 lyophilized
分子量 24.4 kDa
包装 pkg of 20 μg
杂质 endotoxin, tested
UniProt登记号 Q6UXX9
运输 wet ice
储存温度 ?20℃
Gene Information human ... RSPO2(340419)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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