PLGF-3 human

半岛bd体育手机客户端 说明

一般描述

PLGF (placental growth factor), originally identified in human placenta, is a member of the VEGF (vascular endothelial growth factor) family. This protein is predominantly expressed in placenta, and also shows expression in heart, thyroid, lung and skeletal muscle. It is alternatively spliced to produce four isoforms in humans namely, PLGF1, PLGF2, PLGF3 and PLGF4. PLGF gene is localized to human chromosome 14q24, spans 800kb and is composed of seven exons.
Recombinant human PlGF-3 is a 45.7kDa disulfide-linked homodimeric protein of two 203 amino acid polypeptide chains.

生化/生理作用

PLGF (placental growth factor) is involved in angiogenesis, but does not play an essential role in angiogenesis during reproduction and development. However, inactivation of this gene in pathological conditions such as, ischemia, inflammation and cancer, results in impaired angiogenesis. Preclinical studies show that this protein might be a therapeutic target for treatment of angiogenesis and inflammation related disorders. In acute coronary syndrome (ACS) patients, increased levels of PLGF are linked with obstructive sleep apnea (OSA) and short-term adverse outcomes.

序列

LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRHSPGRQS PDMPGDFRAD APSFLPPRRS LPMLFRMEWG CALTGSQSAV WPSSPVPEEI PRMHPGRNGK KQQRKPLREK MKPERCGDAV PRR

外形

Lyophilized with no additives.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed inE. coli
测定	≥95% (HPLC) ≥95% (SDS-PAGE)
形式	lyophilized
效能	5.0-50.0 ng/mL
分子量	45.7 kDa
包装	pkg of 25 μg
technique(s)	cell culture | mammalian: suitable
杂质	<0.1 EU/μg endotoxin, tested
颜色	white
UniProt登记号	P49763
运输	wet ice
储存温度	?20℃
Gene Information	human ... PGF(5228)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable