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Oncostatin-M from rat

品牌
Sigma-Aldrich
货号
SRP3250
规格纯度
recombinant, expressed inE. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
价格
4793.48 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Oncostatin-M from rat
OSM
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

OSM (oncostatin M) is a polypeptide growth factor that belongs to the interleukin-6 cytokine family that includes interleukin-6, interleukin-11, leukemia inhibitory factor, ciliary neurotrophic factor, cardiotrophin-1, and novel neutrophin-1/B-cell-stimulating factor-3. In rats, this protein shows high expression in the late fetal and neonatal testis. It is also expressed at lower levels in the maturing and adult testis. It is also thought to be expressed in Leydig cells in developing testis.
Recombinant rat Oncostatin M is a 24.4kDa protein, containing 215 amino acid residues.

生化/生理作用

OSM (oncostatin M) functions as a ligand for two high affinity heterodimer receptors that share the signal transducing receptor gp130 (glycoprotein). The two receptors are- type I OSM receptor which is a dimer of the gp130 transducing receptor and the LIF (leukocyte inhibitory factor) receptor β-subunit, and the type II OSM receptor which contains a dimer of gp130 and the OSM receptor β-subunit. OSM is produced by neonatal Sertoli cells, where it induces Sertoli cell and gonocyte proliferation. It is responsible for the induction of spermatogenesis, and negates the effect of luteinizing hormone (LH) on Leydig cell progenitor formation, thus, acting as a regulator for this process. Study in rat shows that this protein stimulates the differentiation of OC15-5 (oval cells) into hepatocytes, and therefore, is thought to be key in liver regeneration by promoting oval cell differentiation into hepatocytes.

序列

MKRGCSSSSP KLLSQLKSQA NITGNTASLL EPYILHQNLN TLTLRAACTE HPVAFPSEDM LRQLSKPDFL STVHATLGRV WHQLGAFRQQ FPKIQDFPEL ERARQNIQGI RNNVYCMARL LHPPLEIPEP TQADSGTSRP TTTAPGIFQI KIDSCRFLWG YHRFMGSVGR VFEEWGDGSR RSRRHSPLWA WLKGDHRIRP SRSSQSAMLR SLVPR

外形

Lyophilized with no additives.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 rat
重组 expressed inE. coli
测定 ≥98% (HPLC)
≥98% (SDS-PAGE)
形式 lyophilized
分子量 24.4 kDa
包装 pkg of 10 μg
technique(s) cell culture | mammalian: suitable
杂质 <0.1 EU/μg endotoxin, tested
颜色 white to off-white
UniProt登记号 Q65Z15
运输 wet ice
储存温度 ?20℃
Gene Information rat ... OSM(289747)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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