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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-FLT3 antibody produced in mouse

Monoclonal Anti-FLT3 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1403832
规格纯度
clone 3H1, purified immunoglobulin, buffered aqueous solution
价格
5045.46 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-FLT3 antibody produced in mouse
CD135
FLK2
STK1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. (provided by RefSeq)

免疫原

FLT3 (NP_004110, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
LQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVP

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 3H1, monoclonal
形式 buffered aqueous solution
分子量 antigen ~37 kDa
species reactivity human
technique(s) immunofluorescence: suitable
indirect ELISA: suitable
同位素/亚型 IgG2aκ
NCBI登记号 NM_004119
UniProt登记号 P36888
运输 dry ice
储存温度 ?20℃
Gene Information human ... FLT3(2322)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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