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Monoclonal Anti-CD140a-APC antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700455
规格纯度
clone 16A1, purified immunoglobulin, buffered aqueous solution
价格
5670.5 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Monoclonal Anti-CD140a-APC antibody produced in mouse
Anti-PDGFRA
Anti-PDGF-RA
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The mouse monoclonal antibody 16A1 recognizes CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumours.
Cluster of differentiation 140a (CD140a), also known as platelet-derived growth factor receptor α(PDGFRA), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the receptor tyrosine kinase gene family.

免疫原

CD140a-transfected NIH 3T3 cells

应用

The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (0.25 mL) is sufficient for 25 tests.

生化/生理作用

Platelet-derived growth factor receptor plays a vital role in the development and maturation of platelets. Cluster of differentiation 140a (CD140a)/ PDGFRA acts as a potential target of for imatinib, a revolutionary drug for the treatment of chronic myeloid leukemia. PDGFRA pathway might be involved in developmental process of thrombocytes. The encoded protein facilitates hepatic stellate cell (HSCs) proliferation and migration. Mutation in the gene has been observed in gastrointestinal stromal tumors (GISTs).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 mouse
偶联物 Allophycocyanin conjugate
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 16A1, monoclonal
形式 buffered aqueous solution
species reactivity human
technique(s) flow cytometry: suitable
同位素/亚型 IgG1
NCBI登记号 NM_006206.4
UniProt登记号 P16234
运输 wet ice
储存温度 2-8℃
Gene Information human ... PDGFRA(5156)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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