Monoclonal Anti-CD95 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

CD95, also known as Fas (fatty acid synthase) cell surface death receptor/APO-1, is encoded by the gene mapped to human chromosome 10q23.31. The encoded protein belongs to the tumor necrosis factor receptor superfamily and is expressed on a variety of cells including activated T and B cells. CD95 contains a death domain.
The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.

免疫原

HUT-78 human T cell lymphoma cell line

应用

Monoclonal Anti-CD95 antibody produced in mouse has been used as a apoptosis inducer.

生化/生理作用

CD95/ Fas (fatty acid synthase) cell surface death receptor interacts with its natural ligand (FasL/CD95 L) and plays a vital role in regulation of T-cell homeostasis, by promoting apoptosis via activation-induced cell death (AICD). Mutation in the gene has been associated with the development of Sézary syndrome (SS) and Canale–Smith syndrome. CD95 gene loss can be used as a genetic marker of PSA recurrence after radical prostatectomy.

特点和优势

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外形

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	LT95, monoclonal
形式	buffered aqueous solution
species reactivity	human
浓度	1 mg/mL
technique(s)	flow cytometry: suitable
同位素/亚型	IgG1
NCBI登记号	NM_000043.3
UniProt登记号	P25445
运输	wet ice
储存温度	2-8℃
Gene Information	human ... FAS(355)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable