LIX (CXCL5) from mouse

半岛bd体育手机客户端 说明

一般描述

The murine homolog of ENA-78 is called LIX or chemokine (C-X-C motif) ligand 5 (CXCL5). LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR′ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant murine LIX is a 9.8kDa protein containing 93 amino acid residues.

生化/生理作用

Chemokine (C-X-C motif) ligand 5 (CXCL5) may be involved in neutrophil trafficking in TH17 cell–mediated autoimmunity. It has a role in neutrophil homeostasis at mucosal sites. Murine models of colitis show an increased expression of CXCL5.

序列

APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIIQK ILGSDKKKAK RNALAVERTA SVQ

外形

Lyophilized from 5 mM HoAc.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	mouse
重组	expressed inE. coli
测定	≥98% (HPLC) ≥98% (SDS-PAGE)
形式	lyophilized
分子量	9.8 kDa
包装	pkg of 20 μg
technique(s)	cell culture | mammalian: suitable
杂质	<0.1 EU/μg endotoxin, tested
颜色	white to off-white
UniProt登记号	P50228
运输	wet ice
储存温度	?20℃
Gene Information	mouse ... CXCL5(20311)

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319
预防措施声明	P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
危险分类	Eye Irrit. 2 - Skin Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable