IL-6 from mouse

半岛bd体育手机客户端 说明

一般描述

Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

应用

IL-6 from mouse has been used to study IL-6-mediated inhibition of mouse preadipocyte differentiation.

生化/生理作用

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R and gp130.

外形

Lyophilized from 0.1% TFA

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	mouse
重组	expressed inE. coli
测定	≥98% (HPLC) ≥98% (SDS-PAGE)
形式	lyophilized
效能	5x10^7 units/mg ED50
分子量	21.7 kDa
包装	pkg of 10 μg
杂质	endotoxin, tested
颜色	white to off-white
UniProt登记号	P08505
运输	wet ice
储存温度	?20℃
Gene Information	mouse ... IL6(16193)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable