IL-31 human

半岛bd体育手机客户端 说明

一般描述

IL-31 (interleukin 31) is a T-cell expressed four helix bundle cytokine that functions as a ligand for a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor (OSMR). The latter is expressed in epithelial cells and keratinocytes. IL-31 is a member of the gp130/IL-6 (glycoprotein 130) cytokine family. This protein is released by CD4⁺T cells, and is activated by Th2 (T-helper) cells, peripheral blood and skin-homing CD45RO⁺CLA⁺(cutaneous lymphocyte-associated antigen-positive) T cells and MCs (mast cells).
Recombinant IL-31 is a 15.8kDa protein containing 141 amino acid residues.

生化/生理作用

IL-31 (interleukin 31) is implicated in the pathogenesis of inflammatory disorders such as alopecia, atopic dermatitis, itching, airway hypersensitivity, inflammatory bowel disease, and hepatitis B related liver failure. It is a specific and sensitive marker for tuberculous pleurisy, and is capable of differentiating it from malignant pleural effusion. In humans, this cytokine shows significant elevated expression in pruritic, such as atopic dermatitis, but not in non-pruritic, such as psoriasis, forms of chronic skin inflammation. IL-31 is also implicated in the pathogenesis of chronic spontaneous urticaria, prurigo nodularis, and primary cutaneous lymphomas. Variants in this gene might be linked with the development of mastocytosis and the induction of pruritus in mastocytosis patients.

序列

SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed inE. coli
测定	≥98% (HPLC) ≥98% (SDS-PAGE)
形式	lyophilized
分子量	15.8 kDa
包装	pkg of 10 μg
technique(s)	cell culture | mammalian: suitable
杂质	<0.1 EU/μg endotoxin, tested
颜色	white to off-white
UniProt登记号	Q6EBC2
运输	wet ice
储存温度	?20℃
Gene Information	human ... IL31(386653)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable