IL-22 human

半岛bd体育手机客户端 说明

一般描述

IL22 (interleukin 22) is a member of the IL10 related cytokine family, and this gene is localized to the human chromosome 12q15. This protein is predominantly produced by activated CD4⁺T cells, and its target cells include mesangial, neuronal and hepatoma cell types. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 147 amino acid polypeptide chains.

生化/生理作用

IL22 (interleukin 22) is responsible for eliciting acute-phase responses including, anemia, weight loss, increase in platelet numbers, elevated serum amyloid A and fibrinogen levels and reduced levels serum albumin levels. During inflammation, this protein leads to an increase in pancreatitis-associated protein 1 (PAP1) and osteopontin in pancreatic acinar cells, which might either have protective or trophic effects. This protein is involved in the crosstalk between keratinocytes and inflammatory cells. It is linked with tumorigenesis and progression of tumors. 429 C/T polymorphism in this gene is linked with susceptibility to bladder cancer. In patients with recurrent pregnancy loss, the expression of IL22 is reduced in the uterine decidua, which might lead to disruption of decidual homeostasis, and hence, early loss of pregnancy.

序列

MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI

外形

Lyophilized from 10 mM NaCitrate, pH 3.0

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed inE. coli
测定	≥98% (HPLC) ≥98% (SDS-PAGE)
形式	lyophilized
分子量	32.8 kDa
包装	pkg of 10 μg
technique(s)	cell culture | mammalian: suitable
杂质	<0.1 EU/μg endotoxin, tested
颜色	white to off-white
UniProt登记号	Q9GZX6
运输	wet ice
储存温度	?20℃
Gene Information	human ... IL22(50616)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable